Efficacy And Side Effects Of Yohimbine

Efficacy and side effects of Yohimbine (Can "Yohimbine" cure male impotence)

 

Yohimbine, a stimulant alkaloid. It was first discovered and extracted from the bark of the yohimbe tree in West Africa. In China, there are many names, such as libidin, placenta, and hydroergometrine.

As an alkaloid, the most basic feature of yohimbine is that it possesses biological activity, and in layman’s terms, it has medicinal value. Most of the alkaloids in nature exist in Chinese herbal medicines, which are one of the important active ingredients of Chinese herbal medicines. They can also be extracted and made into western medicines through biochemical techniques, which have certain clinical medicinal value.

For example, ephedrine in ephedra has the effect of relieving asthma; vinblastine in vinca has anticancer activity; berberine in coptis has antibacterial and anti-inflammatory effects; anisodamine has the effect of relieving spasm;

Yohimbine also has biological effects and medicinal value. According to modern pharmacological studies of yohimbine, yohimbine, as an effective α2 adrenergic receptor antagonist, has certain effects in the treatment of male sexual dysfunction. At the same time, according to the records that can be found in the literature, in the past, the medicinal products mainly made of yohimbe through biochemical technology were considered to be effective drugs for the treatment of impotence.

 

So, from the perspective of western medicine, can yohimbine really treat impotence?

To answer this question, first of all we need to briefly understand the physiological mechanism of impotence.

Under normal circumstances, after a normal male receives external sexual stimulation, under the stimulation of the central nervous system, a substance called "NO" will be secreted in the male's local cavernous vascular endothelial cells. "NO" is a vasoactive factor. , has the effect of dilating blood vessels.

But "NO" does not directly dilate blood vessels, its main function is to transmit the signal of blood vessel dilation. After the appearance of "NO", the smooth muscle under the cavernous vascular endothelium receives a signal, and a protein called "cGMP" in the vascular smooth muscle will be activated by "NO", and finally cGMP will directly expand the cavernous vascular smooth muscle. Driven by the expansion of the smooth muscle of the cavernous blood vessels, the cavernous blood vessels directly expand, and then the blood influx maintains sufficient and continuous blood supply to the cavernous blood vessels, providing men with normal sexual life.

The reason for impotence is that the blood vessels in the cavernous body cannot be effectively expanded or cannot be effectively and continuously expanded. There is not enough blood supply to make the cavernous body weak, which makes male impotence unable to live effectively.

 

So can yohimbine, as an a2 receptor antagonist, have the effect of expanding the male cavernous blood vessels?

The answer is that it has an effect, but the effect is very slight. From a pharmacological point of view, the a receptor is simply divided into a1 receptor and a2 receptor. The a1 receptor is a substance that can constrict blood vessels, and the a1 receptor antagonist is "Inhibit" a1 receptors to achieve the purpose of dilating blood vessels. So clinically common a1 receptor antagonist drugs can be used to reduce high blood pressure.

But yohimbine is not a universal a-receptor antagonist, but an a2-receptor antagonist. A2 receptors are not like a1 receptors. A1 receptors are mainly distributed on vascular smooth muscle, while a2 receptors are mainly Distributed in nerve synapses, so yohimbine, as an a2 receptor antagonist, has a limited effect on blood vessel expansion. At the same time, studies have shown that the number of a2 receptors contained in male cavernous tissue is very small, so From the perspective of western medicine, yohimbine cannot effectively expand the male cavernous blood vessels.

 

That being the case, why is Yohimbe online effective in treating impotence?

In fact, although from the perspective of western medicine, yohimbine cannot directly expand the male cavernous blood vessels, so it has little therapeutic effect on organic impotence.

However, from the perspective of yohimbe's natural plant herbs and alkaloids, yohimbe still has a certain effect of promoting libido. As mentioned earlier, yohimbine was actually discovered from the bark of the yohimbe tree in West Africa. It was first found in Africa, and the bark of the yohimbe tree has been known to enhance libido since ancient times. In West Africa, the bark of yohimbe is famous, especially among the African Bantu people as a male sexual dysfunction medicine.

And we know that there are many types of male impotence. In addition to organic impotence caused by the ineffective expansion of cavernous blood vessels, there are also mental impotence caused by mental factors and low libido. The alkaloid effect of yohimbine, from a certain point of view, has a certain promoting effect on mental factors and low libido, so from this point of view, yohimbine has a certain effect on patients with mental impotence .

 

At the same time, clinically, many patients with organic impotence take PDE5 inhibitors such as sildenafil and tadalafil to expand the cavernous blood vessels. Sexual desire, because sexual desire represents the excitement of the central nervous system. Only when the central nervous system is excited, the male corpus cavernosum vascular endothelial cells will secrete the important vasodilator active factor "NO". drugs, which may also lead to ineffectiveness of the drug. From this perspective, it can be proved once again that yohimbine has a certain auxiliary effect on male impotence.

 

So, can yohimbine be used to treat male impotence?

In essence, the treatment of impotence cannot be considered solely from vascular response, nor can it be considered solely from mental and emotional factors. In other words, although yohimbine is an a2 receptor antagonist, it has no obvious effect of expanding the smooth muscle of cavernous blood vessels in essence. Therefore, from the perspective of western medicine, there is no diagnosis and treatment guideline recommending yohimbine for the treatment of impotence. There are also limitations on yohimbine options for treating impotence.

At the same time, although yohimbine has an alkaloid effect, and old books have recorded that it can increase sexual desire, it does not mean that it can treat impotence. In fact, sexual excitement is a wide range of physiological processes, including various brains, hormones, emotions, etc. , nerve, muscle and blood vessel reactions, as long as one of them goes wrong, it may cause impotence, so the treatment of impotence cannot be stimulated blindly from mental factors.

Foreign research data pointed out that the effect of yohimbine on improving impotence ranges from 34% to 73%, which is highly random, and most of these effective cases are related to psychological impotence (non-organic). In a controlled study (30 days in 20 patients with organic impotence), high doses of yohimbine were not effective in improving impotence compared to placebo. A recent foreign double-blind controlled study pointed out (for a period of 4 weeks, the subjects were 40 patients with mild to moderate impotence), yohimbine and arginine can help improve impotence, but the long-term therapeutic effect is unknown.

 

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